Crystal structure of glycoprotein E2 from bovine viral diarrhea virus
نویسندگان
چکیده
منابع مشابه
Crystal structure of glycoprotein E2 from bovine viral diarrhea virus.
Pestiviruses, including bovine viral diarrhea virus, are important animal pathogens and are closely related to hepatitis C virus, which remains a major global health threat. They have an outer lipid envelope bearing two glycoproteins, E1 and E2, required for cell entry. They deliver their genome into the host cell cytoplasm by fusion of their envelope with a cellular membrane. The crystal struc...
متن کاملPersistent bovine viral diarrhea virus (BVDV) infection in cattle herds
Bovine viral diarrhea virus (BVDV) is a significant pathogen associated with gastrointestinal, respiratory, and reproductive diseases of cattle worldwide. It causes continuous economic losses to the cattle industry primarily due to decreased reproductive performance. The ability of virus to cross the placenta during early pregnancy can result in the birth of persistently infected (PI) calves. P...
متن کاملDetection of Bovine Viral Diarrhea Virus in Bovine Semen Using Nested-PCR
A rapid and sensitive reverse transcription polymerase chain reaction (RT-PCR) and nested-PCR were used to detect bovine viral diarrhea virus 1 (BVDV-1) in bull semen. Selected primers could amplify a part of the 5´UTR of the BVDV genome. A 294 bp DNA fragment was amplified and specificity of the results was confirmed by direct sequencing of the PCR product. Prior to RNA extraction, the seminal...
متن کاملThe effect of bovine viral diarrhea virus on bovine monocyte phenotype
Bovine viral diarrhea virus (BVDV) is an economically important pathogen of the livestock industry worldwide. BVDV is classified into cytopathic (cp) and noncytopathic (ncp), depending on its effects on cultured cells. BVDV is known to alter the host’s immune response. Of this, major histocompatibility complex (MHC) class II molecules play a central role in the development and function of the i...
متن کاملDiagnosis of Bovine Viral Diarrhea Virus:
Bovine viral diarrhea virus (BVDV) is one of the most important viral pathogens of cattle worldwide. Because of the insidious and complex nature of BVDV, laboratory diagnosis is critical in preventing and controlling BVDV infections. These same characteristics often make laboratory diagnosis challenging. A firm understanding of the disease is required to select the appropriate diagnostic strate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1300524110